Frequency and impact of enteric hyperoxaluria in pediatric short bowel syndrome: a retrospective single centre study

Objectives The survival of pediatric patients with short bowel syndrome has improved in recent years. Enteric hyperoxaluria as a pathophysiological consequence been hardly addressed so far. It can be associated nephrolithiasis, nephrocalcinosis or even renal insufficiency. We assessed the prevalence and its pathogenic consequences retrospective single centre study over last 12 Methods conducted an internal database search for all suffering from treated 2010 to 2022 department gastroenterology well nephrology dialysis unit. Out 56 identified, 26 were analysed etiology syndrome, excretion oxalate (24/26), remaining large intestinal length further clinical parameters such eGFR, nephrocalcinosis/urinary stone formation stool frequency. Results Hyperoxaluria was detected 14/26 (54%). Nephrocalcinosis present four patients. these patients, could proven (21% hyperoxaluric patients) three cases, one patient had nephrolithiasis (7%). In lead end stage disease. found that 80% volvulus developed enteric hyperoxaluria. None investigated factors effect on excretion. Conclusion is relevant finding occurring about 50% our cohort multiple complications. Regular screening may implemented medical care syndrome. If necessary, prophylaxis, e.g., dietary advice metaphylaxis should initiated.